Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu; Ping Zhao; Neng Liu; Fumi Yoshino; Hongmei Qin; Yajuan Zou; Shengwei Shi; Tsukuru Amano; Jose R. Aguilar Cosme; Yasunobu Nagano; Hitoshi Tamiaki; Naoki Komatsu

doi:10.1088/2053-1583/ab377b

Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

Gang Liu, Ping Zhao, Neng Liu, Fumi Yoshino, Hongmei Qin, Yajuan Zou, Shengwei Shi, Tsukuru Amano, Jose R. Aguilar Cosme, Yasunobu Nagano, Hitoshi Tamiaki, Naoki Komatsu

研究成果 › 査読

8 被引用数 (Scopus)

抄録

Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e ₆ (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS₂) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS₂-Ir. We observed that MoS₂-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

本文言語	English
論文番号	045035
ジャーナル	2D Materials
巻	6
号	4
DOI	https://doi.org/10.1088/2053-1583/ab377b
出版ステータス	Published - 2019
外部発表	はい

ASJC Scopus subject areas

化学 (全般)
材料科学（全般）
凝縮系物理学
材料力学
機械工学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1088/2053-1583/ab377b

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@article{7147a9a5a31f42c8be6a6af896d8b281,

title = "Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property",

abstract = "Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.",

keywords = "2D nanosheet, anticancer drug, photodynamic therapy, photosensitizer, phototherapy, photothermal therapy",

author = "Gang Liu and Ping Zhao and Neng Liu and Fumi Yoshino and Hongmei Qin and Yajuan Zou and Shengwei Shi and Tsukuru Amano and {Aguilar Cosme}, {Jose R.} and Yasunobu Nagano and Hitoshi Tamiaki and Naoki Komatsu",

note = "Publisher Copyright: {\textcopyright} 2019 IOP Publishing Ltd.",

year = "2019",

doi = "10.1088/2053-1583/ab377b",

language = "English",

volume = "6",

journal = "2D Materials",

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TY - JOUR

T1 - Photosensitizer and anticancer drug-loaded 2D nanosheet

T2 - Preparation, stability and anticancer property

AU - Liu, Gang

AU - Zhao, Ping

AU - Liu, Neng

AU - Yoshino, Fumi

AU - Qin, Hongmei

AU - Zou, Yajuan

AU - Shi, Shengwei

AU - Amano, Tsukuru

AU - Aguilar Cosme, Jose R.

AU - Nagano, Yasunobu

AU - Tamiaki, Hitoshi

AU - Komatsu, Naoki

PY - 2019

Y1 - 2019

N2 - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

AB - Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.

KW - 2D nanosheet

KW - anticancer drug

KW - photodynamic therapy

KW - photosensitizer

KW - phototherapy

KW - photothermal therapy

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Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property

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ASJC Scopus subject areas

UN SDG

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