TY - JOUR
T1 - Platelet Adhesion on Metal Oxide Layers
AU - Takemoto, S.
AU - Yamamoto, T.
AU - Tsuru, K.
AU - Hayakawa, S.
AU - Osaka, A.
PY - 2004
Y1 - 2004
N2 - This study was concerned with blood compatibility of titanium oxide layers on stainless steel. The titanium oxide layers were prepared through sol-gel process by dip-coating of tetraethyltitanate solution and heated at 500°C. The crystal phase, thickness and wettability of the oxide were characterized. The blood compatibility was evaluated in term of platelet adhesion using human platelet rich plasma. Consequently, with increase in the thickness of the titanium oxide layers, the number of platelet adhered on the stainless steel coated with titanium oxide layer decreased rapidly, When the thickness of titanium oxide layers on stainless steel grew more than 150 nm, the number of adherent platelets decreased less than 10% in comparison with that on non-coated stainless steel. The titanium oxide layers indicated to be more hydrophilic than non-coated stainless steel. In conclusion, the thicker and more hydrophilic titanium oxide layer on stainless steel appears to inhibit platelet adhesion.
AB - This study was concerned with blood compatibility of titanium oxide layers on stainless steel. The titanium oxide layers were prepared through sol-gel process by dip-coating of tetraethyltitanate solution and heated at 500°C. The crystal phase, thickness and wettability of the oxide were characterized. The blood compatibility was evaluated in term of platelet adhesion using human platelet rich plasma. Consequently, with increase in the thickness of the titanium oxide layers, the number of platelet adhered on the stainless steel coated with titanium oxide layer decreased rapidly, When the thickness of titanium oxide layers on stainless steel grew more than 150 nm, the number of adherent platelets decreased less than 10% in comparison with that on non-coated stainless steel. The titanium oxide layers indicated to be more hydrophilic than non-coated stainless steel. In conclusion, the thicker and more hydrophilic titanium oxide layer on stainless steel appears to inhibit platelet adhesion.
KW - Platelet adhesion
KW - Sol-gel coating
KW - Titanium oxide layer
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M3 - Conference article
AN - SCOPUS:0347516119
SN - 1013-9826
VL - 254-256
SP - 853
EP - 856
JO - Key Engineering Materials
JF - Key Engineering Materials
T2 - The Annual Meeting of the International Society for Ceramics in Medicine
Y2 - 6 November 2003 through 9 November 2003
ER -