Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer

Tomoko Haruma; Keiichiro Nakamura; Takeshi Nishida; Chikako Ogawa; Tomoyuki Kusumoto; Noriko Seki; Yuji Hiramatsu

Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer

Tomoko Haruma
, Keiichiro Nakamura
, Takeshi Nishida
, Chikako Ogawa
, Tomoyuki Kusumoto
, Noriko Seki
, Yuji Hiramatsu

研究成果 › 査読

抄録

Background/Aim: Inflammation and tumor immunology are important in the prognosis of various cancers. We herein investigated whether pre-treatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and serum cancer antigen 125 (CA125) predict recurrence and survival in patients with endometrial cancer (EC).

Patients and Methods: We collected complete blood counts and clinicopathological data from medical records of 320 patients with EC; their pre-treatment NLR, PLR and CA125 were analyzed for correlations with recurrence and survival, retrospectively.

Results: Disease-free survival (DFS) and overall survival (OS) rates of patients with high NLR and CA125 were significantly shorter than those for patients with low NLR and CA125 (DFS: p=0.002 and p<0.001; OS: p<0.001 and p<0.001, respectively). Furthermore, NLR was also an independent predictive factor for mortality in multivariate analysis (hazard ratio (HR)=3.318; 95% confidence interval (CI)=1.154-9.538; p=0.026).

Conclusion: Pre-treatment NLR is a predictor of poor prognosis in EC.

本文言語	English
ページ（範囲）	337-344
ページ数	8
ジャーナル	Anticancer research
巻	35
号	1
出版ステータス	Published - 1月 1 2015

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ASJC Scopus subject areas

腫瘍学
癌研究

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title = "Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer",

abstract = "Background/Aim: Inflammation and tumor immunology are important in the prognosis of various cancers. We herein investigated whether pre-treatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and serum cancer antigen 125 (CA125) predict recurrence and survival in patients with endometrial cancer (EC).Patients and Methods: We collected complete blood counts and clinicopathological data from medical records of 320 patients with EC; their pre-treatment NLR, PLR and CA125 were analyzed for correlations with recurrence and survival, retrospectively.Results: Disease-free survival (DFS) and overall survival (OS) rates of patients with high NLR and CA125 were significantly shorter than those for patients with low NLR and CA125 (DFS: p=0.002 and p<0.001; OS: p<0.001 and p<0.001, respectively). Furthermore, NLR was also an independent predictive factor for mortality in multivariate analysis (hazard ratio (HR)=3.318; 95\% confidence interval (CI)=1.154-9.538; p=0.026).Conclusion: Pre-treatment NLR is a predictor of poor prognosis in EC.",

keywords = "Endometrial cancer, Neutrophil to lymphocyte ratio, Prognosis",

author = "Tomoko Haruma and Keiichiro Nakamura and Takeshi Nishida and Chikako Ogawa and Tomoyuki Kusumoto and Noriko Seki and Yuji Hiramatsu",

year = "2015",

month = jan,

day = "1",

language = "English",

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pages = "337--344",

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TY - JOUR

T1 - Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer

AU - Haruma, Tomoko

AU - Nakamura, Keiichiro

AU - Nishida, Takeshi

AU - Ogawa, Chikako

AU - Kusumoto, Tomoyuki

AU - Seki, Noriko

AU - Hiramatsu, Yuji

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background/Aim: Inflammation and tumor immunology are important in the prognosis of various cancers. We herein investigated whether pre-treatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and serum cancer antigen 125 (CA125) predict recurrence and survival in patients with endometrial cancer (EC).Patients and Methods: We collected complete blood counts and clinicopathological data from medical records of 320 patients with EC; their pre-treatment NLR, PLR and CA125 were analyzed for correlations with recurrence and survival, retrospectively.Results: Disease-free survival (DFS) and overall survival (OS) rates of patients with high NLR and CA125 were significantly shorter than those for patients with low NLR and CA125 (DFS: p=0.002 and p<0.001; OS: p<0.001 and p<0.001, respectively). Furthermore, NLR was also an independent predictive factor for mortality in multivariate analysis (hazard ratio (HR)=3.318; 95% confidence interval (CI)=1.154-9.538; p=0.026).Conclusion: Pre-treatment NLR is a predictor of poor prognosis in EC.

AB - Background/Aim: Inflammation and tumor immunology are important in the prognosis of various cancers. We herein investigated whether pre-treatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and serum cancer antigen 125 (CA125) predict recurrence and survival in patients with endometrial cancer (EC).Patients and Methods: We collected complete blood counts and clinicopathological data from medical records of 320 patients with EC; their pre-treatment NLR, PLR and CA125 were analyzed for correlations with recurrence and survival, retrospectively.Results: Disease-free survival (DFS) and overall survival (OS) rates of patients with high NLR and CA125 were significantly shorter than those for patients with low NLR and CA125 (DFS: p=0.002 and p<0.001; OS: p<0.001 and p<0.001, respectively). Furthermore, NLR was also an independent predictive factor for mortality in multivariate analysis (hazard ratio (HR)=3.318; 95% confidence interval (CI)=1.154-9.538; p=0.026).Conclusion: Pre-treatment NLR is a predictor of poor prognosis in EC.

KW - Endometrial cancer

KW - Neutrophil to lymphocyte ratio

KW - Prognosis

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UR - https://www.scopus.com/pages/publications/84920500400#tab=citedBy

M3 - Article

C2 - 25550569

AN - SCOPUS:84920500400

SN - 0250-7005

VL - 35

SP - 337

EP - 344

JO - Anticancer research

JF - Anticancer research

IS - 1

ER -

Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer

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