Prospective evaluation of endoscopic criteria characteristic of sessile serrated adenomas/polyps

Toshio Uraoka, Reiji Higashi, Joichiro Horii, Keita Harada, Keisuke Hori, Hiroyuki Okada, Motowo Mizuno, Jun Tomoda, Nobuya Ohara, Takehiro Tanaka, Han Mo Chiu, Naohisa Yahagi, Kazuhide Yamamoto


43 被引用数 (Scopus)


Background: Differentiating sessile serrated adenoma/polyp (SSA/P) from hyperplastic polyp (HP) is clinically important in determining the necessity of endoscopic resection or recommending appropriate surveillance. There are few reports of characterization of SSA/P using narrowband imaging and chromoendoscopy with and without magnification. We aimed to establish imaging criteria to aid real-time diagnosis of SSA/P. Methods: Patients with pale sessile or flat lesions of 6 mm or greater were prospectively enrolled in this multicenter trial. Nine endoscopic criteria, determined in real time, were investigated for possible association with SSA/P. Endoscopic mucosal resection was performed; specimens were retrieved and analyzed by histopathological examination. Results: In 63 patients, 89 lesions were detected, including 41 HP, 38 SSA/P, five mixed polyps, and five other lesions. Right-side colon location, lesion size of 10 mm or greater, excessive mucus, the presence of a varicose microvascular vessel (VMV) noted with high-magnification narrowband imaging, and type IIIH pit pattern were each commonly associated with SSA/P compared with HP. Multivariate analysis substantiated three independent endoscopic criteria for SSA/P: the presence of VMV (p = 0.001), lesion size of 10 mm or greater (p = 0.0017), and right-side location (p = 0.0041), with odds ratios of 8.2, 7.2, and 6.1, respectively. The presence of VMV had a significantly higher specificity (87.8 %) than the other two independent endoscopic criteria (p = 0.0007 and p = 0.0008, respectively), but a lower sensitivity (57.9 %), whereas a combination of the three criteria (two or more positive) increased the sensitivity significantly (89.5 % and p = 0.0033) and had a higher degree of accuracy (82.3 %). Conclusions: Three endoscopic criteria individually and in combination were effective in predicting a diagnosis of SSA/P without the need for chromoendoscopy.

ジャーナルJournal of Gastroenterology
出版ステータスPublished - 5月 1 2015

ASJC Scopus subject areas

  • 消化器病学


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