The reaction of 1,2,3,4-tetrahydroquinazoline-2-spirocyclohexan-4-one (1b) with acetic anhydride and pyridine gave 1-(1-cyclohexenyl)-2-methyl-1,4-dihydroquinazolin-4-one (3b). Compound 3b gave 3-acetyl-1-(1-cyclohexenyl)-2-methyl-1,2,3,4-tetrahydroquinazolin-4-one (8b) upon reduction with NaBH4 followed by acetylation with acetic anhydride. The position of the acetyl group of 8b was determined by comparison of its NMR spectrum with those of related compounds (9, 10, 11, 12, and 13).
|ジャーナル||Chemical and Pharmaceutical Bulletin|
|出版ステータス||Published - 1981|
ASJC Scopus subject areas
- 化学 (全般)