Reconstruction of action potential of repolarization in patients with congenital long-QT syndrome

Akihiko Kandori, Wataru Shimizu, Miki Yokokawa, Shiro Kamakura, Kunio Miyatake, Masahiro Murakami, Tsuyoshi Miyashita, Kuniomi Ogata, Keiji Tsukada


1 被引用数 (Scopus)


A method for reconstructing an action potential during the repolarization period was developed. This method uses a current distribution - plotted as a current-arrow map (CAM) - calculated using magnetocardiogram (MCG) signals. The current arrows are summarized during the QRS complex period and subtracted during the ST-T wave period in order to reconstruct the action-potential waveform. To ensure the similarity between a real action potential and the reconstructed action potential using CAM, a monophasic action potential (MAP) and an MCG of the same patient with type-I long-QT syndrome were measured. Although the MAP had one notch that was associated with early afterdepolarization (EAD), the reconstructed action potential had two large and small notches. The small notch timing agreed with the occurrence of the EAD in the MAP. On the other hand, the initiation time of an abnormal current distribution coincides with the appearance timing of the first large notch, and its end time coincides with that of the second small notch. These results suggest that a simple reconstruction method using a CAM based on MCG data can provide a similar action-potential waveform to a MAP waveform without having to introduce a catheter.

ジャーナルPhysics in Medicine and Biology
出版ステータスPublished - 5月 21 2004

ASJC Scopus subject areas

  • 放射線技術および超音波技術
  • 放射線学、核医学およびイメージング


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