Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma

Tadashi Hanafusa, Yasuhiro Yumoto, Kazuhiro Nouso, Harushige Nakatsukasa, Toru Onishi, Tatsuya Fujikawa, Mayumi Taniyama, Shinichiro Nakamura, Masayuki Uemura, Yoshitaka Takuma, Eiichiro Yumoto, Toshihiro Higashi, Takao Tsuji

研究成果査読

115 被引用数 (Scopus)

抄録

Insulin-like growth factor binding protein-3 (IGFBP-3) is postulated to be a mediator of growth suppression signals. Reduced expression of the IGFBP-3 was observed in nine out of 12 human hepatocellular carcinomas (HCC) (75%). Promoter hypermethylation of the IGFBP-3 was detected in four out of 12 HCCs (33%) although mutations were not identified. The expression of IGFBP-3 was restored by the demethylating agent 5-aza-2′-deoxycytidine in HCC cell line with promoter hypermethylation (HepG2). As IGFBP-3 functions like a tumor suppressor gene, it may be used as a therapeutic target for HCC.

本文言語English
ページ(範囲)149-158
ページ数10
ジャーナルCancer Letters
176
2
DOI
出版ステータスPublished - 2月 25 2002

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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