Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat

W. R. Zhang, T. Hayashi, J. M. Wang, C. Sasaki, K. Sakai, H. Warita, Y. Shiro, H. Suenaga, H. Ohmae, S. Tsuji, T. Itoh, O. Nishimura, H. Nagasaki, K. Abe

研究成果査読

4 被引用数 (Scopus)

抄録

Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 μg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P=0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions. Copyright (C) 1999 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)161-164
ページ数4
ジャーナルNeuroscience Letters
276
3
DOI
出版ステータスPublished - 12月 10 1999

ASJC Scopus subject areas

  • 神経科学(全般)

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