TY - JOUR
T1 - Regenerative medicine for epilepsy
T2 - From basic research to clinical application
AU - Yasuhara, Takao
AU - Agari, Takashi
AU - Kameda, Masahiro
AU - Kondo, Akihiko
AU - Kuramoto, Satoshi
AU - Jing, Meng
AU - Sasaki, Tatsuya
AU - Toyoshima, Atsuhiko
AU - Sasada, Susumu
AU - Sato, Kenichiro
AU - Shinko, Aiko
AU - Wakamori, Takaaki
AU - Okuma, Yu
AU - Miyoshi, Yasuyuki
AU - Tajiri, Naoki
AU - Borlongan, Cesario V.
AU - Date, Isao
PY - 2013/11/28
Y1 - 2013/11/28
N2 - Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.
AB - Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.
KW - Brain-derived neurotrophic factor (BDNF)
KW - Electrical stimulation
KW - Erythropoietin
KW - GABAergic neuron
KW - Kainic acid
KW - Kindling
KW - Neural stem cell
UR - https://www.scopus.com/pages/publications/84888618231
UR - https://www.scopus.com/pages/publications/84888618231#tab=citedBy
U2 - 10.3390/ijms141223390
DO - 10.3390/ijms141223390
M3 - Review article
C2 - 24287913
AN - SCOPUS:84888618231
SN - 1661-6596
VL - 14
SP - 23390
EP - 23401
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 12
ER -