抄録
One attractive approach to anticancer therapy is repression of expression of vascular endothelial growth factor (VEGF) gene, which is a potent target for prevention of tumor growth. To achieve this, artificial transcription factors (ATF) designed for VEGF gene regulation were fused to cell-penetrating peptides (CPPs). We demonstrated ATFs fused to CPPs, designated CPP-ATFs or designed regulatory proteins (DRPs), could penetrate into mammalian cells and transiently repress expression of a reporter gene, which was under control of the VEGF promoter/5'-UTR. We discuss gene-regulatory properties of CPP-ATFs in detail.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 291-292 |
| ページ数 | 2 |
| ジャーナル | Nucleic acids symposium series (2004) |
| 号 | 50 |
| DOI | |
| 出版ステータス | Published - 2006 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 医学（全般）
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
