Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats

Hikaru Sada, Nobuaki Egashira, Soichiro Ushio, Takehiro Kawashiri, Masafumi Shirahama, Ryozo Oishi

研究成果査読

14 被引用数 (Scopus)

抄録

Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.

本文言語English
ページ(範囲)547-551
ページ数5
ジャーナルJournal of Pharmacological Sciences
118
4
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

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