Secondary c-kit mutation in a recurrent gastrointestinal stromal tumor under long-term treatment with imatinib mesylate: Report of a case

Tohru Utsunomiya, Masahiro Okamoto, Shuya Yano, Toshihumi Kameyama, Ayumi Matsuyama, Sosei Kuma, Manabu Yamamoto, Megumu Fujiwara, Teruyoshi Ishida

研究成果査読

12 被引用数 (Scopus)

抄録

Gastrointestinal stromal tumors (GISTs) commonly harbor oncogenic mutations of the c-kit receptor gene, which are targets for imatinib mesylate. However, imatinib resistance is an increasing clinical problem. We herein present such a case with a recurrent GIST, in association with the development of a secondary mutation in the c-kit gene. A 67-year-old man, who had a GIST of the stomach with multiple liver metastases, underwent a partial gastrectomy, distal pancreatectomy, and partial hepatectomy. After surgery, he was treated with imatinib. However, during the approximately 4-year treatment period, a recurrence of the GIST in the liver was detected, for which a partial hepatectomy was again performed. The primary GIST constitutively had a deletion mutation in exon 11. In addition, the recurrent hepatic tumor developed a secondary point mutation (Val654Ala) in exon 13, which may be responsible for the imatinib resistance.

本文言語English
ページ(範囲)65-67
ページ数3
ジャーナルSurgery today
38
1
DOI
出版ステータスPublished - 1月 2008
外部発表はい

ASJC Scopus subject areas

  • 外科

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