@article{a208e2773691417dad0f38a5ee7faa3d,
title = "Secondary pulmonary alveolar proteinosis associated with primary myelofibrosis and ruxolitinib treatment: An autopsy case",
abstract = "Pulmonary alveolar proteinosis (PAP) is an uncommon lung disorder characterized by the excessive accumulation of surfactant-derived lipoproteins in the pulmonary alveoli and terminal bronchiole. Secondary PAP associated with primary myelofibrosis (PMF) is extremely rare, and to our knowledge, no autopsy case has been reported. We herein report an autopsy case of secondary PAP occurring in a patient with PMF who was treated with the Janus kinase 1/2 inhibitor ruxolitinib. We confirmed a diagnosis of PAP with complications based on the pathological findings at the autopsy. Notably, this case might suggest an association between ruxolitinib treatment and PAP occurrence.",
keywords = "Autopsy, Primary myelofibrosis, Pulmonary alveolar proteinosis, Ruxolitinib",
author = "Hiroyuki Sugiura and Hisakazu Nishimori and Kazuya Nishii and Tomohiro Toji and Keiko Fujii and Nobuharu Fujii and Matsuoka, {Ken Ichi} and Koh Nakata and Katsuyuki Kiura and Yoshinobu Maeda",
note = "Publisher Copyright: {\textcopyright} The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/ by-nc-nd/4.0/)",
year = "2020",
doi = "10.2169/internalmedicine.4082-19",
language = "English",
volume = "59",
pages = "2023--2028",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "16",
}