TY - JOUR
T1 - Sex difference in hepatic microsomal aldehyde oxygenase activity in different strains of mice
AU - Watanabe, K.
AU - Matsunaga, T.
AU - Narimatsu, S.
AU - Yamamoto, I.
AU - Yoshimura, H.
PY - 1992/12/1
Y1 - 1992/12/1
N2 - Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.
AB - Hepatic microsomal oxidation of 11-oxo-Δ8-tetrahydrocannabinol (11-oxo- Δ8-THC) and 9-anthraldehyde (9-AA) to the corresponding carboxylic acids was investigated using six strains of male and female mice (ddN, ddY, C57BL, DBA, C3H and ICR). No significant sex difference was observed in the activity toward 11-oxo-Δ8-THC except for ICR, whereas the activity toward 9-AA was significantly higher in female than in male of ddN, C57BL, DBA and C3H mice. The present study suggests that female specific form(s) of cytochrome P450 may be responsible at least in part for the microsomal oxidation of 9-AA, but not that of 11-oxo-Δ8-THC.
UR - http://www.scopus.com/inward/record.url?scp=0027104402&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027104402&partnerID=8YFLogxK
M3 - Article
C2 - 1335600
AN - SCOPUS:0027104402
SN - 0034-5164
VL - 78
SP - 373
EP - 376
JO - Research Communications in Chemical Pathology and Pharmacology
JF - Research Communications in Chemical Pathology and Pharmacology
IS - 3
ER -