TY - JOUR
T1 - Soft-tissue sarcoma in adolescents and young adults
AU - Kunisada, Toshiyuki
AU - Nakata, Eiji
AU - Fujiwara, Tomohiro
AU - Hosono, Ako
AU - Takihira, Shota
AU - Kondo, Hiroya
AU - Ozaki, Toshifumi
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI, Grant-in-Aid for Scientific Research (C) (T. Kunisada, No. 19K09650).
Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Japan Society of Clinical Oncology.
PY - 2022
Y1 - 2022
N2 - Soft-tissue sarcoma is a rare cancer that accounts for approximately 1% of all malignant tumors. Although they occur in various age groups, soft-tissue sarcomas account for 8% of all malignant tumors developing in adolescents and young adults, suggesting that they are not rare in this age group. This study aimed to evaluate the clinical and pathological characteristics of soft-tissue sarcoma in adolescents and young adults. According to the Bone and Soft-Tissue Tumor Registry in Japan, myxoid liposarcoma is the most common type of soft-tissue sarcoma found in adolescents and young adults; alveolar soft part sarcoma, extraskeletal Ewing sarcoma, epithelioid sarcoma, clear cell sarcoma and synovial sarcoma occur predominantly in this age group among soft-tissue sarcomas. The analysis based on this registry demonstrated that age was not a prognostic factor for poor survival of soft-tissue sarcoma, although the prognosis in adolescents and young adults was better than that in older patients in the US and Scandinavia. Adolescent and young adult patients with soft-tissue sarcoma have age-specific problems, and a multidisciplinary approach to physical, psychological, and social issues is necessary to improve the management of these young patients both during and after treatment.
AB - Soft-tissue sarcoma is a rare cancer that accounts for approximately 1% of all malignant tumors. Although they occur in various age groups, soft-tissue sarcomas account for 8% of all malignant tumors developing in adolescents and young adults, suggesting that they are not rare in this age group. This study aimed to evaluate the clinical and pathological characteristics of soft-tissue sarcoma in adolescents and young adults. According to the Bone and Soft-Tissue Tumor Registry in Japan, myxoid liposarcoma is the most common type of soft-tissue sarcoma found in adolescents and young adults; alveolar soft part sarcoma, extraskeletal Ewing sarcoma, epithelioid sarcoma, clear cell sarcoma and synovial sarcoma occur predominantly in this age group among soft-tissue sarcomas. The analysis based on this registry demonstrated that age was not a prognostic factor for poor survival of soft-tissue sarcoma, although the prognosis in adolescents and young adults was better than that in older patients in the US and Scandinavia. Adolescent and young adult patients with soft-tissue sarcoma have age-specific problems, and a multidisciplinary approach to physical, psychological, and social issues is necessary to improve the management of these young patients both during and after treatment.
KW - Adolescents and young adults
KW - Sarcoma
KW - Soft tissue
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U2 - 10.1007/s10147-022-02119-7
DO - 10.1007/s10147-022-02119-7
M3 - Review article
C2 - 35084598
AN - SCOPUS:85123911873
SN - 1341-9625
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
ER -
