Spontaneous foaming during vacuum drying of polyvinylpyrrolidone- and sugar-alcohol mixtures and enhancement of water-dissolution of water insoluble drug

Olivier Tramis, Akiho Fujioka, Hiroyuki Imanaka, Naoyuki Ishida, Koreyoshi Imamura

研究成果査読

4 被引用数 (Scopus)

抄録

We experimentally investigate the foamability of PVP 2.5k/ethanol and amorphous α-maltose/methanol solution under moderate vacuum. We investigate the influence of the solution concentration and the impact of the container shape on the foamability. We show that spontaneous foaming is strongly influenced by the container’s shape. The concentration of the solution is another important parameter, and our results suggest that, for a given solution, there seems to be only a narrow concentration window that enables the formation of a stable foam. When loaded with a model hydrophobic drug (ibuprofen), the spontaneous foaming enhances the dispersion of the drug molecules, by acting as an additional mixing force through extensive shear of the solution.

本文言語English
ページ(範囲)604-614
ページ数11
ジャーナルDrying Technology
40
3
DOI
出版ステータスPublished - 2022

ASJC Scopus subject areas

  • 化学工学一般
  • 物理化学および理論化学

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