Stearylamine Changes the Liposomal Shape from MLVs to LUVs

Shoko Yokoyama, Akiko Inagaki, Koji Tsuchiya, Hideki Sakai, Tomohiro Imura, Takahiro Ohkubo, Nobuyuki Tsubaki, Masahiko Abe

研究成果査読

11 被引用数 (Scopus)

抄録

The shape of mixed dipalmitoylphosphatidylcholine (DPPC)/stearylamine (SA) liposomes prepared by the Bangham method was examined using freeze-fracture electron microscopy. The shape of the mixed DPPC/SA liposomes (XSA = 0.05) was not that of multilamellar vesicles (MLVs) but large unilamellar vesicles (LUVs) with a diameter of approximately 1.0 μm. These facts overthrow the preconceived idea that the shape of the DPPC/SA liposomes prepared by the Bangham method is that of MLVs. The trapping efficiency of the mixed DPPC/SA liposomes (XSA = 0.05) was ten times greater than that of the DPPC liposomes, since the DPPC liposomes were MLVs. The data of the DSC peak for the DPPC/SA liposomes also indicated that the shape of the DPPC/SA liposomes is that of LUVs. We emphasize that the shape of the DPPC liposomes changes from that of MLVs to LUVs by the mixing of a small amount of SA into the DPPC liposomes.

本文言語English
ページ(範囲)251-254
ページ数4
ジャーナルJournal of Oleo Science
54
4
DOI
出版ステータスPublished - 2005
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 化学工学(全般)

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