Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s

Engineering & Materials Science

• Cytochrome P-450 Enzyme System 88%
• Dehydrogenation 16%
• Enantiomers 42%
• Hydroxylation 65%
• Ketones 17%
• Liver 43%
• Mammals 16%
• Metabolic Networks and Pathways 16%
• Metabolism 15%
• Metabolites 49%
• Molecules 23%
• Oxidation 42%
• Proteins 43%
• Stereoselectivity 100%
• Substrates 33%

Chemical Compounds

• Blocking Agent 5%
• Bufuralol 84%
• Column Like Crystal 2%
• Cytochrome 41%
• Cytochrome P450 9%
• Dehydrogenation 3%
• Diastereomer 8%
• Drug 2%
• Enantiomer 6%
• Ethyl Group 5%
• Metabolic 7%
• Metabolite 9%
• Molecule 3%
• Oxidation Reaction 21%
• Pharmacological Metabolism 3%
• Racemate 10%
• Stereoselectivity 44%

Medicine & Life Sciences

• 1'-oxobufuralol 0%
• Adrenergic Receptors 6%
• bufuralol 83%
• Cytochrome P-450 CYP1A2 2%
• Cytochrome P-450 CYP2C19 2%
• Cytochrome P-450 CYP2D6 2%
• Cytochrome P-450 Enzyme System 8%
• Cytochromes 55%
• High Pressure Liquid Chromatography 1%
• hydroxide ion 7%
• Hydroxylation 7%
• In Vitro Techniques 0%
• Ketones 2%
• Kinetics 1%
• Liver 2%
• Liver Microsomes 2%
• Mammals 1%
• Metabolic Networks and Pathways 2%
• Metabolome 2%
• Methanol 2%
• Pharmaceutical Preparations 0%
• Pharmacology 1%
• Ro 03-7410 4%