Study on Biologic Effects of Radon and Thermal Therapy on Osteoarthritis

Kiyonori Yamaoka, Fumihiro Mitsunobu, Katsumi Hanamoto, Shuji Mori, Yoshiro Tanizaki, Katsuhiko Sugita


57 被引用数 (Scopus)


Radon therapy uses radon (222Rn) gas, which mainly emits α-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain. Perspective: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis.

ジャーナルJournal of Pain
出版ステータスPublished - 2月 2004

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学
  • 麻酔学および疼痛医療


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