TY - JOUR
T1 - Synthesis and biological activity of mycalolide analogs
AU - Suenaga, Kiyotake
AU - Kimura, Tomoyuki
AU - Kuroda, Takeshi
AU - Matsui, Keita
AU - Miya, Saori
AU - Kuribayashi, Satomi
AU - Sakakura, Akira
AU - Kigoshi, Hideo
N1 - Funding Information:
We are grateful to Professors Hiroshi Ozaki and Masatoshi Hori (The University of Tokyo) for their donation of actin and their helpful advice and discussions. This study was supported in part by the 21st Century COE program and Grants-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology, The Asahi Glass Foundation, Suntory Institute for Bioorganic Research, Astellas Foundation for Research on Medicinal Resources, Shorai Foundation for Science and Technology, TARA project (University of Tsukuba), and Research Fellowships of the Japan Society for the Promotion of Science for Young Scientists (JSPS) to T.K. Finally, we thank Ms. Shoko Ueda, Mr. Tomohisa Handa, and Mr. Kengo Kanematsu for their technical assistance.
PY - 2006/8/28
Y1 - 2006/8/28
N2 - Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The analog 4 was found to have strong actin-depolymerizing activity.
AB - Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The analog 4 was found to have strong actin-depolymerizing activity.
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U2 - 10.1016/j.tet.2006.06.046
DO - 10.1016/j.tet.2006.06.046
M3 - Article
AN - SCOPUS:33745968785
SN - 0040-4020
VL - 62
SP - 8278
EP - 8290
JO - Tetrahedron
JF - Tetrahedron
IS - 35
ER -
