Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu; Masayasu Kuwahara; Masahiko Sisido; Teruhiko Ishikawa

doi:10.1246/cl.2001.634

Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu, Masayasu Kuwahara, Masahiko Sisido, Teruhiko Ishikawa

研究成果 › 査読

13 被引用数 (Scopus)

抄録

A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A₉)] hybridized with the complementary DNA (T₉). The hybrid showed a very sharp melting curve with T_m = 34 °C.

本文言語	English
ページ（範囲）	634-635
ページ数	2
ジャーナル	Chemistry Letters
号	7
DOI	https://doi.org/10.1246/cl.2001.634
出版ステータス	Published - 1月 1 2001

ASJC Scopus subject areas

化学 (全般)

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10.1246/cl.2001.634

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abstract = "A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.",

author = "Masanori Shigeyasu and Masayasu Kuwahara and Masahiko Sisido and Teruhiko Ishikawa",

year = "2001",

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AU - Sisido, Masahiko

AU - Ishikawa, Teruhiko

PY - 2001/1/1

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N2 - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

AB - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

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Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

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