Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Seisuke Takashima; Y. Kusudo; S. Takemoto; K. Tsuru; S. Hayakawa; A. Osaka

Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

Seisuke Takashima, Y. Kusudo, S. Takemoto, K. Tsuru, S. Hayakawa, A. Osaka

研究成果 › 査読

抄録

Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N₂ containing 0%, 5%, or 15% CO₂ by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO₄^3- and OH^- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β₂-microgloburin (β₂-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β₂-MG (47%). It was concluded that the selective adsorption activity against β₂-MG was related to the carbonate ions incorporated in hydroxyapatite.

本文言語	English
ページ（範囲）	175-178
ページ数	4
ジャーナル	Key Engineering Materials
巻	218-220
出版ステータス	Published - 2002
イベント	14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) - Palm Springs, CA 継続期間: 11月 14 2001 → 11月 17 2001

ASJC Scopus subject areas

材料科学一般
材料力学
機械工学

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title = "Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances",

abstract = "Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.",

keywords = "Blood Compatibility, Bovine Serum Albumin, Carbonate-Hydroxy Apatite, Hydroxyapatite, β-Microgloburin",

author = "Seisuke Takashima and Y. Kusudo and S. Takemoto and K. Tsuru and S. Hayakawa and A. Osaka",

year = "2002",

language = "English",

volume = "218-220",

pages = "175--178",

journal = "Key Engineering Materials",

issn = "1013-9826",

publisher = "Trans Tech Publications Ltd",

note = "14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM) ; Conference date: 14-11-2001 Through 17-11-2001",

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TY - JOUR

T1 - Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

AU - Takashima, Seisuke

AU - Kusudo, Y.

AU - Takemoto, S.

AU - Tsuru, K.

AU - Hayakawa, S.

AU - Osaka, A.

PY - 2002

Y1 - 2002

N2 - Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.

AB - Hydroxyapatite (HAP) and carbonate-hydroxy apatite (CAP5 and CAP15) were synthesized under the flow of N2 containing 0%, 5%, or 15% CO2 by wet chemical method, and subsequently calcined at 105-700°C. Infrared analysis showed that carbonate ions substituted PO43- and OH- sites. The clotting characteristics for the fresh mixed plasma contacted with the samples indicated that CAP had better blood compatibility than HAP. The protein adsorption activity was evaluated by contacting with the model saline containing bovine serum albumin (BSA) and β2-microgloburin (β2-MG). CAP15 calcined below 600°C adsorbed the lowest fraction of BSA (9%) whereas it adsorbed the highest fraction of β2-MG (47%). It was concluded that the selective adsorption activity against β2-MG was related to the carbonate ions incorporated in hydroxyapatite.

KW - Blood Compatibility

KW - Bovine Serum Albumin

KW - Carbonate-Hydroxy Apatite

KW - Hydroxyapatite

KW - β-Microgloburin

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M3 - Conference article

AN - SCOPUS:18144440413

SN - 1013-9826

VL - 218-220

SP - 175

EP - 178

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - 14th International Symposium on Ceramics in Medicine-Annual Meeting of the International Society for Ceramics in Medicine BIOCERAMICS'01 (ISCM)

Y2 - 14 November 2001 through 17 November 2001

ER -

Synthesis of carbonate-hydroxy apatite and selective adsorption activity against specific pathogenic substances

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