tele‐Methylhistamine Levels and Histamine Turnover in Nuclei of the Rat Hypothalamus and Amygdala

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki

研究成果査読

7 被引用数 (Scopus)

抄録

An HPLC method using fluorescence detection for the determination of tele‐methylhistamine! (t‐MH) was improved to a sensitivity level which enabled the detection of 0.05 pmol of tissue t‐MH. The t‐MH contents and the histamine turnover rates in various nuclei of the rat hypothalamus and amygdala were subsequently measured. The histamine turnover rates were estimated from pargyline‐induced t‐MH accumulation. Both the t‐MH levels and the histamine turnover rates were shown to be relatively high in the nuclei dorsomedialis and premammillaris ventralis of the hypothalamus, and also in the nucleus medialis of the amygdala. The steady‐state t‐MH levels in various nuclei of the hypothalamus and amygdala correlated well with the histamine turnover rates in these nuclei.

本文言語English
ページ(範囲)844-848
ページ数5
ジャーナルJournal of Neurochemistry
53
3
DOI
出版ステータスPublished - 9月 1989

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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