Terahertz aptasensor for dopamine neurochemical detection

Measuring neurotransmitter levels in the body can identify imbalances and diagnose neurological and psychiatric disorders. Several advanced imaging technologies and electrochemical and optical sensors have been developed for a highly sensitive and selective detection of neurotransmitters. In this study, a terahertz chemical microscope (TCM) for measurement of dopamine levels is proposed. The TCM uses terahertz waves to obtain a label-free chemical reaction on a sensing plate. A DNA aptamer is investigated as a recognition element for detection of dopamine. The measurement mechanism and construction of the terahertz aptasensor are described, providing a potential alternative for neurotransmitter detection.