The ability of transplanted bone marrow-derived cells to differentiate into parenchymal cells of salivary glands

Yao Wei Yuan, Ryo Tamamura, Lei Lei, Naoki Katase, Gulsan Ara Sathi, Satoshi Ito, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka

研究成果査読

3 被引用数 (Scopus)

抄録

Salivary glands are important exocrine glands for oral health and initial digestion. Salivary gland dysfunction resulting from irreversible glandular damage usually leads to poor life quality in patients. Recent investigations showed that bone marrow-derived cells (BMDCs) could be grafted into non-hematopoietic cells in multiple tissues. In this study, BMDCs from green fluorescent protein (GFP) mice were transplanted into irradiated C57BL/6 mice to assess the ability of BMDCs to differentiate into parenchymal cells of salivary glands by immunohistochemistry and double fluorescent staining. The data revealed that a population of GFP positive cells showed the characteristics of acinar cells, ductal cells and myoepithelial cells in parotid and submandibular glands, and that some of BMDCs presented amylase expression. These results showed that BMDCs have the ability to differentiate into parenchymal cells of salivary glands with certain glandular cell functions. Such plasticity of BMDCs can be the first step for salivary gland regeneration by stem cells and tissue engineering therapy.

本文言語English
ページ(範囲)433-438
ページ数6
ジャーナルJournal of Hard Tissue Biology
22
4
DOI
出版ステータスPublished - 2013

ASJC Scopus subject areas

  • 医学(その他)
  • 生化学
  • 生体材料
  • 整形外科およびスポーツ医学
  • 歯学一般
  • 細胞生物学

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