TY - JOUR
T1 - The association between hypothyroidism and proteinuria in patients with chronic kidney disease
T2 - a cross-sectional study
AU - Matsuoka-Uchiyama, Natsumi
AU - Tsuji, Kenji
AU - Sang, Yizhen
AU - Takahashi, Kensaku
AU - Fukushima, Kazuhiko
AU - Takeuchi, Hidemi
AU - Inagaki, Kenichi
AU - Uchida, Haruhito A.
AU - Kitamura, Shinji
AU - Sugiyama, Hitoshi
AU - Wada, Jun
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disease (CKD) patients. We conducted a cross-sectional study composed of 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion (UP) and thyroid function tests. Spearman correlation analysis revealed that 24-h Cr clearance (24hrCcr) was positively (r = 0.273, p < 0.001) and UP was negatively (r = − 0.207, p < 0.001) correlated with free triiodothyronine. Frequency distribution analysis stratified by CKD stage and UP for hypothyroidism revealed that the prevalence of hypothyroidism was higher among participants with higher CKD stage and nephrotic range proteinuria. Multivariate logistic regression analysis revealed that 24hrCcr and UP were significantly correlated with hypothyroidism (24hrCcr/10 mL/min decrease: odds ratio [OR], 1.29; 95% confidence interval [CI], 1.18–1.41; UP/1 g increase: OR, 1.10; 95% CI, 1.03–1.17). In addition, nephrotic range proteinuria, but not moderate UP (UP: 1.5–3.49 g/day), was significantly correlated with hypothyroidism compared to UP < 0.5 g/day. In summary, decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria, are independently associated with the hypothyroidism.
AB - Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disease (CKD) patients. We conducted a cross-sectional study composed of 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion (UP) and thyroid function tests. Spearman correlation analysis revealed that 24-h Cr clearance (24hrCcr) was positively (r = 0.273, p < 0.001) and UP was negatively (r = − 0.207, p < 0.001) correlated with free triiodothyronine. Frequency distribution analysis stratified by CKD stage and UP for hypothyroidism revealed that the prevalence of hypothyroidism was higher among participants with higher CKD stage and nephrotic range proteinuria. Multivariate logistic regression analysis revealed that 24hrCcr and UP were significantly correlated with hypothyroidism (24hrCcr/10 mL/min decrease: odds ratio [OR], 1.29; 95% confidence interval [CI], 1.18–1.41; UP/1 g increase: OR, 1.10; 95% CI, 1.03–1.17). In addition, nephrotic range proteinuria, but not moderate UP (UP: 1.5–3.49 g/day), was significantly correlated with hypothyroidism compared to UP < 0.5 g/day. In summary, decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria, are independently associated with the hypothyroidism.
UR - https://www.scopus.com/pages/publications/85137152405
UR - https://www.scopus.com/pages/publications/85137152405#tab=citedBy
U2 - 10.1038/s41598-022-19226-0
DO - 10.1038/s41598-022-19226-0
M3 - Article
C2 - 36056164
AN - SCOPUS:85137152405
SN - 2045-2322
VL - 12
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 14999
ER -