The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

Medicine & Life Sciences

• Alzheimer Disease 26%
• Amyloid Precursor Protein Secretases 86%
• Caenorhabditis elegans 19%
• Cultured Cells 14%
• Double-Stranded RNA 20%
• Drosophila 32%
• Drosophila melanogaster 75%
• Drosophila Psn protein 41%
• Fibroblasts 12%
• Genes 20%
• Loss of Function Mutation 19%
• Mammals 61%
• Molecular Weight 58%
• Mutation 9%
• Notch Receptors 24%
• Peptides 11%
• Phenotype 10%
• Point Mutation 16%
• Presenilin-1 48%
• Presenilins 100%
• RNA Interference 16%

Chemical Compounds

• Cleavage 15%
• Mutation 58%
• Polypeptide 19%
• Protein 9%
• Weight 36%