The role of the cAMP-PKA system in the short-term regulation of striatal [14C]-2-deoxyglucose uptake in freely moving rats

Rie Hosoi, Sotaro Momosaki, Nobuhiro Ibii, Kohji Abe, Takashi Itoh, Osamu Inoue

研究成果査読

7 被引用数 (Scopus)

抄録

The cyclic adenosine monophosphate (cAMP)-protein kinase (PK) A system has been shown to have stimulatory effects on glucose utilization in various tissues in vitro. However, little is known about the influence of cAMP on glucose utilization in vivo. In the present study, we examined how cAMP-related compounds affected [14C]-2-deoxyglucose (DG) uptake in the striatum of freely moving rats. An intrastriatal injection of dibutyryl-cyclic adenosine monophosphate (db-cAMP), although increasing local cerebral blood flow, was found to decrease the uptake of [14C]-2-DG in the striatum. This decrease of [14C]-2-DG uptake in the striatum was completely blocked by pretreatment with Rp-adenosine-3′,5′-cyclic monophosphorothioate triethylamine (Rp-cAMPS). Moreover, intrastriatal infusion of Rp-cAMPS alone produced a striking increase of [14C]-2-DG uptake in the striatum. These results strongly suggest that transient activation of the cAMP-PKA system can depress the glucose phosphorylation process of the rat brain in vivo.

本文言語English
ページ(範囲)260-263
ページ数4
ジャーナルBrain Research
921
1-2
DOI
出版ステータスPublished - 12月 7 2001
外部発表はい

ASJC Scopus subject areas

  • 神経科学一般
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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