Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats

W. R. Zhang; H. Kitagawa; T. Hayashi; C. Sasaki; K. Sakai; H. Warita; Y. Shiro; H. Suenaga; H. Ohmae; S. Tsuji; T. Itoh; O. Nishimura; H. Nagasaki; K. Abe

doi:10.1016/S0006-8993(99)01818-1

Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats

W. R. Zhang, H. Kitagawa, T. Hayashi, C. Sasaki, K. Sakai, H. Warita, Y. Shiro, H. Suenaga, H. Ohmae, S. Tsuji, T. Itoh, O. Nishimura, H. Nagasaki, K. Abe

研究成果 › 査読

29 被引用数 (Scopus)

抄録

In order to examine the effect of neurotrophin-3 (NT-3) on ischemic brain injury, NT-3 was topically applied to brain surface just after 90 min of middle cerebral artery occlusion (MCAO) in rats. NT-3 significantly reduced the infarct size at 24 h of reperfusion. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick labeling (TUNEL) staining and immunohistochemical study for caspase-3 and heat shock protein 72 (HSP72) showed that NT-3 treatment decreased the number of cells with DNA fragmentation and caspase-3 and HSP72 expressions. These data suggest that NT-3 protects neuronal cells from ischemic injury, and it is possibly associated with inhibition of DNA fragmentation.

本文言語	English
ページ（範囲）	211-214
ページ数	4
ジャーナル	Brain Research
巻	842
号	1
DOI	https://doi.org/10.1016/S0006-8993(99)01818-1
出版ステータス	Published - 9月 18 1999

ASJC Scopus subject areas

神経科学（全般）
分子生物学
臨床神経学
発生生物学

文献へのアクセス

10.1016/S0006-8993(99)01818-1

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引用スタイル

Zhang, W. R., Kitagawa, H., Hayashi, T., Sasaki, C., Sakai, K., Warita, H., Shiro, Y., Suenaga, H., Ohmae, H., Tsuji, S., Itoh, T., Nishimura, O., Nagasaki, H., & Abe, K. (1999). Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats. Brain Research, 842(1), 211-214. https://doi.org/10.1016/S0006-8993(99)01818-1

Zhang, WR, Kitagawa, H, Hayashi, T, Sasaki, C, Sakai, K, Warita, H, Shiro, Y, Suenaga, H, Ohmae, H, Tsuji, S, Itoh, T, Nishimura, O, Nagasaki, H & Abe, K 1999, 'Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats', Brain Research, vol. 842, no. 1, pp. 211-214. https://doi.org/10.1016/S0006-8993(99)01818-1

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abstract = "In order to examine the effect of neurotrophin-3 (NT-3) on ischemic brain injury, NT-3 was topically applied to brain surface just after 90 min of middle cerebral artery occlusion (MCAO) in rats. NT-3 significantly reduced the infarct size at 24 h of reperfusion. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick labeling (TUNEL) staining and immunohistochemical study for caspase-3 and heat shock protein 72 (HSP72) showed that NT-3 treatment decreased the number of cells with DNA fragmentation and caspase-3 and HSP72 expressions. These data suggest that NT-3 protects neuronal cells from ischemic injury, and it is possibly associated with inhibition of DNA fragmentation.",

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author = "Zhang, {W. R.} and H. Kitagawa and T. Hayashi and C. Sasaki and K. Sakai and H. Warita and Y. Shiro and H. Suenaga and H. Ohmae and S. Tsuji and T. Itoh and O. Nishimura and H. Nagasaki and K. Abe",

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