@article{0136fa983cae47d3906c021383e2872f,
title = "ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell-mediated innate immune response in human hepatocytes",
abstract = "Natural killer (NK) cells through their NK group 2 member D (NKG2D) receptors recognize NKG2D ligands such as UL16-binding proteins (ULBPs) on virus-infected cells and subsequently trigger the host innate immune response. In the present study, we demonstrated that hepatitis C virus (HCV) induced the cell surface expression of ULBP1 in human immortalized hepatocyte PH5CH8 cells and human hepatoma HuH-7 cell-derived RSc cells. Interestingly, NK cell line NK-92 induced cytotoxicity and interferon-γ mRNA expression and subsequently reduced the levels of HCV RNA replication during co-culture with HCV-infected RSc cells. From these results, we conclude that ULBP1 is a target of the NK cell-mediated innate immune response in HCV-infected human hepatocytes.",
keywords = "HCV RNA replication, NK cell, ULBP1, hepatitis C virus, innate immune response",
author = "Hiromichi Dansako and Hirotaka Imai and Youki Ueda and Shinya Satoh and Takaji Wakita and Nobuyuki Kato",
note = "Funding Information: We thank Marie Iwado, Masayo Takemoto, Hiroki Hiramoto and Takashi Nakamura for their technical assistance. We also thank Dr Tsuyoshi Akagi for pCX4bsr, pCX4pur and pCX4bleo retroviral vectors. This work was supported by the Practical Research on Hepatitis from Japan Agency for Medical Research and Development (AMED), and by JSPS KAKENHI Grant Number 15K08498. Publisher Copyright: {\textcopyright} 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.",
year = "2018",
month = mar,
doi = "10.1002/2211-5463.12373",
language = "English",
volume = "8",
pages = "361--371",
journal = "FEBS Open Bio",
issn = "2211-5463",
publisher = "Elsevier BV",
number = "3",
}
