Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum

Masayuki Sakurai, Takashi Ohtsuki, Tsutomu Suzuki, Kimitsuna Watanabe

研究成果査読

24 被引用数 (Scopus)

抄録

To understand the decoding property of nematode mitochondrial tRNAs with unusual secondary structures, post-transcriptional modifications at wobble positions of Ascaris suum mitochondrial tRNAs corresponding to two-codon families ending with a purine were analyzed. 5-Carboxymethylaminomethyluridine (cmnm5U) was identified at the wobble positions of tRNA Lys, tRNAGlu and tRNAGln, while 5-carboxymethylaminomethyl-2-thiouridine (cmnm5s2U) was present in tRNAUAALeuandtRNATrp. In most bacterial and mitochondrial tRNAs, the 2-thiouridine derivative is present in tRNAs for Lys, Glu and Gln. These is no report that cmnm5s2U is used in tRNAUAALeuandtRNATrp. The unusual usage of wobble modifications might assist decoding of nematode mitochondrial mRNAs.

本文言語English
ページ(範囲)2767-2772
ページ数6
ジャーナルFEBS Letters
579
13
DOI
出版ステータスPublished - 5月 23 2005

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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