Valvular regurgitation in patients with Kawasaki disease and in healthy children: A pulsed Doppler echocardiographic study

T. Akagi, O. Inoue, N. Ohara, O. Toyoda, N. Rikitake, T. Mikajima, K. Suzuki, H. Kato

研究成果査読

5 被引用数 (Scopus)

抄録

Valvular lesions in the acute stage of Kawasaki disease were observed using pulsed Doppler echocardiography. The subjects consisted of 65 patients with Kawasaki disease (2 months~62/12 years) who had been followed from the acute stage. The age-matched 113 controls were selected from 661 healthy children (2 months~14 years of age). In the acute stage of Kawasaki disease, tricuspid regurgitation (TR) was detected in 31 (48%), pulmonary regurgitation (PR) in 22 (34%) and mitral regurgitation (MR) in 17 (26%). There was no aortic regurgitation (AR). In the convalescent stage, TR was found in 26 (40%), PR in 20 (31%), and MR in 11 (17%), but no AR was detected. The incidence of each valvular regurgitation between the acute and convalescent stages in patients with Kawasaki disease did not differ significantly. Furthermore, there was no significant difference in the incidence of valvular regurgitation between patients with Kawasaki disease and the normal controls. In nine patients, however, valvular regurgitation in the acute stage had disappeared by the convalescent stage, and two patients had developed a new pansystolic murmur in the acute stage. We estimated the incidence of pathologic valvular involvement in Kawasaki disease to be 11/65 (17%). The incidence of valvular involvement in patients with coronary artery aneurysms was significantly higher than that of patients without coronary artery aneurysms (p<0.01). It was concluded that mild and transient valvular regurgitation, which cannot be detected by auscultation, may occur in some patients in the acute stage of Kawasaki disease. These may be caused by acute inflammation of the valve related to coronary artery lesions. In view of the Doppler echocardiographic findings in normal controls, these regurgitations should be distinguished from ''physiological'' ones.

本文言語English
ページ(範囲)787-796
ページ数10
ジャーナルJournal of cardiology
19
3
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

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