Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

Yu Matsumoto, Joseph W. Nichols, Kazuko Toh, Takahiro Nomoto, Horacio Cabral, Yutaka Miura, R. James Christie, Naoki Yamada, Tadayoshi Ogura, Mitsunobu R. Kano, Yasuhiro Matsumura, Nobuhiro Nishiyama, Tatsuya Yamasoba, You Han Bae, Kazunori Kataoka


287 被引用数 (Scopus)


Enhanced permeability in tumours is thought to result from malformed vascular walls with leaky cell-to-cell junctions. This assertion is backed by studies using electron microscopy and polymer casts that show incomplete pericyte coverage of tumour vessels and the presence of intercellular gaps. However, this gives the impression that tumour permeability is static amid a chaotic tumour environment. Using intravital confocal laser scanning microscopy we show that the permeability of tumour blood vessels includes a dynamic phenomenon characterized by vascular bursts followed by brief vigorous outward flow of fluid (named 'eruptions') into the tumour interstitial space. We propose that 'dynamic vents' form transient openings and closings at these leaky blood vessels. These stochastic eruptions may explain the enhanced extravasation of nanoparticles from the tumour blood vessels, and offer insights into the underlying distribution patterns of an administered drug.

ジャーナルNature Nanotechnology
出版ステータスPublished - 6月 1 2016

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 原子分子物理学および光学
  • 生体医工学
  • 材料科学(全般)
  • 凝縮系物理学
  • 電子工学および電気工学


「Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。