Vitamin B-12-deficiency affects immunoglobulin production and cytokine levels in mice

U. Funada, M. Wada, T. Kawata, K. Mori, H. Tamai, T. Isshiki, J. Onoda, N. Tanaka, T. Tadokoro, A. Maekawa

研究成果査読

15 被引用数 (Scopus)

抄録

To clarify the role of B-12 in the immunological function, serum C3, IgM, IgG, IgE Contents, splenocytes expression of CD4, CD8, and CD4 positive intracellular IFN-γ and IL-4 were examined in B-12-deficient mice, and the effect of the administration of CH3-B-12 was also studied. Serum C3, IgM and IgG contents were lower in B-12-deficient mice than in the control mice. On the other hand, serum IgE content was sinificantly higher in B-12-deficient mice, and the value in CH3-B-12 administered mice, administered CH3-B-12 to B-12-deficient mice for 48 h before the end of feeding period, showed a tendency to recovery. CD4+CDS- cells and CD4+CDS-/CD4-CD8+ ratio in splenocytes were significantly higher in B-12-deficient mice than in control mice. CD4+IFN-γ+ cells was significantly lower in B-12-deficient mice than in control mice, and CD4+IL-4+ was significantly higher in B-12-deficient mice than in control mice. These results suggest that B-12-deficiency causes CD4+CDS-T cells shift from the T helper type 1 to the T helper type 2, which participate in the IgE production and elevates CD4+CDS-/CD4-CD8+ratio. Thus, B-12 plays a role in maintaining the immune function in mice.

本文言語English
ページ(範囲)60-65
ページ数6
ジャーナルInternational Journal for Vitamin and Nutrition Research
71
1
DOI
出版ステータスPublished - 1月 1 2001

ASJC Scopus subject areas

  • 医学(その他)
  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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