TY - JOUR
T1 - β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions
AU - Ozawa, Nobuaki
AU - Makino, Tsunehisa
AU - Matsubayashi, Hidehiko
AU - Hosokawa, Tomotoshi
AU - Someya, Ken‐Ichi ‐I
AU - Nozawa, Shiro
AU - Matsuura, Eiji
PY - 1994
Y1 - 1994
N2 - We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.
AB - We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.
KW - SLE (systemic lupus erythematosus)
KW - antiphospholipid syndrome
KW - cofactor
KW - habitual abortion
KW - thrombosis
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U2 - 10.1002/jcla.1860080502
DO - 10.1002/jcla.1860080502
M3 - Article
C2 - 7807278
AN - SCOPUS:0027989440
SN - 0887-8013
VL - 8
SP - 255
EP - 259
JO - Journal of Clinical Laboratory Analysis
JF - Journal of Clinical Laboratory Analysis
IS - 5
ER -
